These variations are changes in our genetic structure that we have inherited from parents, just like we inherit the color of our eyes.Our genes contain the instructions for how proteins are to be made, and these instructions are spelled out in a special gene-alphabet that contains just four letters: G, A, T, and C. G A T and C stand for four different nucleic acids that make up all our genes, and these are: Guanine for the G, Adenine for the A, Thymine for the T, and Cytosine for the C. Changing the order in which these nucleic acids appear in a gene by moving just one nucleic acid, say for example, having an A for Adenine appear in a lineup in the spot where a G for Guanine, would normally appear can change the instructions that the gene gives for how the protein should be made. And these changes are called Single-Nucleotide Polymorphisms, or SNPS, because what is changed is the position of a nucleic acid in the gene.
But while such a change seems really small, very tiny, it can make a huge difference in the way that the protein that is produced by the instructions sent by that gene actually functions.SNPS in certain genes involved in the way that our body produces, uses, or clears out vitamin K can greatly affect our requirements for vitamin K; what form of vitamin K might work best for us and how much vitamin K we need to support our health. If you want all the details on this, I wrote about it in depth in Your Bones in the 2nd edition, but here I’m just going to give you the bottom line. There are SNPS in four genes that have been identified that impact how much vitamin K you require to have healthy bones. These SNPS produce variations in: apolipoprotein E which you may have heard of as APOE, the vitamin K epoxide reductase or the VKOR enzyme, the gamma-glutamyl carboxylase enzyme, and the cytochrome P450 4F2 enzyme. In the next four videos (one, two, three, and four), we’re going to talk about each of these enzymes and the variations in them, the SNPS for them, and how each of those impacts your needs for vitamin K2. I’ll also be giving some clues to try and figure out which SNPS variations you have, or if you have the common version of these enzymes. I hope this was interesting and helpful, and I hope you’ll tune in to learn more about each of these SNPS. Thanks.
Sources: Pizzorno L. Your Bones, pp. 188-196. Shearer MJ, Fu X, Booth SL. Vitamin K nutrition, metabolism, and requirements: current concepts and future research. Adv Nutr. 2012 Mar 1;3(2):182-95. doi: 10.3945/an.111.001800. PMID: 22516726