Denosumab Associated with Dermatologic Toxicity – FDA Adverse Events Reporting System

Hi Debbie, the Sam’s vitamin has such small amounts of these nutrients, it should not be an issue. Re vit D (what form? D3 is way more active than D2; D2 is cheaper so is used in lesser quality supps) and vit K (again what form? 25 mcg of MK-4 is meaningless — if taking MK-4 you require 15 milligrams taken 3 times daily for a total of 45 milligrams per day, thus 25 micrograms is meaningless), 25 mcg of MK-7 is better but still far less than the 90-100 mcg shown in the research to be helpful)

The form of vit K in your multiple is K1 NOT either form of K2. K1 does have some beneficial effects on bone as it is anti-inflammatory, but K1 will not activate the proteins that put calcium into bone (osteocalcin) and keep it out of arteries, kidneys, breasts and your brain (matrix Gla protein). For this you need at least 100 mcg of K2 as MK-7 or 15 mg of K2 taken three times daily (every 6 hours) if as MK-4. Who at AlgaeCal advised you to not take more K2 than is supplied in AlgaeCal Plus — this is incorrect information unless you are taking this anticoagulant in which case, you can still use K2 as MK-7 but should be doing so with doctor supervision to ensure your INR remains stable. If on Coumadin, the dose recommended of MK-7 is 90 mcg/day. For everyone else, K2 (MK-7) is very safe. In studies using more than 800 mcg daily no side effects have been seen. In Japan, people regularly eat natto — a one cup serving of natto delivers more than 400 mcg of MK-7.
Re vitamin D3, the only way to tell if you are getting sufficient amounts of vit D is to have your blood drawn to check your levels of 25(OH)D — this is the form of vit D in the circulation. Optimal levels are 60-80 ng/mL. This blood test should be covered by your insurance. Most people need at least 2,000 IU of D3 daily to get into this range. Many need 5,000 IU or even 10,000 IU per day to get into optimal range. I have explained all this at length in Your Bones — the book will be available at your library if you do not wish to purchase a copy; it is published by Praktikos, a non-profit, and costs less than $10.00.

You’re so welcome! Hope Your Bones will help you make more sense of what your bones need to rebuild healthfully and safely. Don’t hesitate to ask if you have further questions. Be well! Lara

Hello Pierre,
Instances of DRESS or DVT have been reported in the medical literature only for strontium ranelate.
No reports of these ADRs or cardiovascular problems have been made for strontium citrate.

However, each of us is unique, and even a compound that is safe and effective for 100,000,000 people may cause some kind of reaction in the 100,000,001 person who uses it. I have only had one such report. A woman contacted me about 6 months ago – hundreds of people have written me since Your Bones was published – to let me know that she had developed swollen lymph glands after taking strontium citrate. When she discontinued it, the swelling quickly resolved.

Since your BMD has not yet improved with only AlgaeCal Plus, my suggestion to you is to try strontium citrate as it may be very helpful for you and is highly unlikely to cause any adverse effects. To be on the extra cautious side, start out with half or even one-quarter of the recommended dosage for one month. Then gradually increase over several weeks to the full dosage.

Most importantly, if you do not yet know why you are losing excessive amounts of bone, please read Part III (where I discuss the numerous factors that increase your risk for osteoporosis) in the 2nd edition of Your Bones, and also look at the Labs Appendix, in which I explain the key labs that can help you (and your doctor) determine why YOU are losing bone. My dear friend, Dr. Sidney Baker, MD, would have you think about it this way – if you are sitting on 2 tacks (one being insufficient nutrients your bones need – and AlgaeCal Plus / Strontium Boost should help address this – and a second tack being – we don’t know), then removing just one tack is not going to make the pain (bone loss) go away. You must remove both tacks to heal.

So, please read Your Bones and feel free to write me with any questions you have as to what you think might be the remaining “tack” or “tacks”; I am happy to do my best to help you determine the underlying causes of your excessive bone loss,

Lara