Bone-Healthy Living / Research / May 8, 2012

Recent findings from study conducted by researchers at University of Alberta, Canada points that heart failure patients are at increased risk of developing osteoporosis. In a study that observed 45, 500 adults over a period of ten years, it was found that heart failure is linked to thinning and weakening of the bones over a period of time and thus heart failure patients should be screened for osteoporosis at regular intervals. Of the population observed in the study, approximately 1,840 persons had recently had one episode of heart failure. The whole population studied were screened for bone mineral density, many of who were having the test done the first time in their lives. After a follow up of a decade, data showed that those with heart failure were associated with at least a 30% increased risk of developing major fractures…

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Nutrition / Research / Vitamin D3 / May 8, 2012

Study conducted at the Children’s Hospital Boston showed some surprising results when Kendrin R. Sonneville, Sc.D., R.D and his colleagues examined the relation between risk of stress fractures in growing girls and their intake of calcium, Vitamin D and/or dairy products. (4) Stress fractures usually occur due to overuse of a particular bone or set of bones. In other words, they arise out of repeated strain on a bone. Stress fractures are incomplete fractures and occur when muscles become fatigued due to overuse/repeat movement without adequate rest and recovery. These muscles are unable to absorb shock of the movement and transfer the repeat stress overload to the bones which develop microscopic cracks or fractures. They most commonly occur in the lower leg and feet. High impact physical activities such as running on hard surfaces, tennis, squash, basketball put one to…

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Nutrition / Research / Strontium / May 8, 2012

The European Medicine Agency (EMA) has issued cautionary advice to doctors on prescribing strontium ranelate, sold under brand names Osseor or Protelos by Les Labaratoires Servier, to those who are immobilised, have or run the risk of venous thromboembolism. The warning prohibits doctors from prescribing this strontium ranelate to such patients. Venous thromboembolism is a deadly condition that occurs in those who have been admitted to hospitals for long and even those at home who are immobile due to any health condition. It includes both pulmonary embolism as well as deep vein thrombosis. Strontium ranelate is used in the treatment of osteoporosis in premenopausal women so that they run a lower risk of hip or spinal fractures. Strontium ranelate has a dual function in that it increases the production of bone-forming cells osteoblast and reduces osteoclast production or cells that…

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Bone-Healthy Living / Research / March 23, 2012

Biphosphonate class drug Boniva also sold worldwide under the brand names Bonviva and Bondronat is now available for sale in the United States. The Food and Drug Administration has approved it’s use – prescription by doctors and distribution in pharmacies for sale in the prevention and treatment of osteoporosis in post-menopausal women. (1) The primary chemical compound in Boniva is ibandronate sodium. The drug is not prescribed for men unless they are participating in clinical trials. The drug approved by FDA is the generic version of Boniva which are essentially tablets of ibandronate. This makes the drug more affordable through cheaper pricing. According to Keith Webber, Ph.D., deputy director of the Office of Pharmaceutical Science in the FDA’s Center for Drug Evaluation and Research, “Men as well as women are affected by osteoporosis, a disease that can be prevented and…

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Bone-Healthy Living / Research / March 23, 2012

While most of the focus on osteoporosis in terms of reported cases, diagnosis, treatment, research and cost burdens have been in the US and Europe, the latest audit report (October 2011) from International Osteoporosis Foundation (IOF) shows that Middle East and Africa regions are getting left behind in the global effort towards tackling osteoporosis. The data on the markers mentioned were collected from 17 countries of the region including Turkey. Analysis done for individual countries as well as for the regions showed alarming forecasts of fractures to be brought on by osteoporosis. The predictions show that as many as 25% of the region’s population over the age of 50 years will be diagnosed with osteoporosis by as soon as 2020. The percentage will be a staggering 40% for the same age group by 2050. (1) According to lead author of…

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Bone-Healthy Living / Research / March 23, 2012

A bone growth molecule has now been developed by the scientific community which once injected into the bloodstream, ‘directs’ stem cells in the bone marrow to form more bones. The UC Davis Health System scientists have created this novel technique. The bone growth molecule which is injected is a hybrid molecule (or a double-stranded nucleic acid molecule which is made by man from two different single-stranded nucleic acid molecules of different sources). This hybrid molecule was ‘created’ by Kit Lam, professor and chair of the UC Davis Department of Biochemistry and Molecular Medicine. (1) Though the experiments conducted by the researchers were on mouse model, they hold promise as an osteoporosis treatment for human beings especially in cases where bone density and strength are compromised with aging, estrogen deficiency and long-term use of steroid for treatment of chronic conditions. During…

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Bone-Healthy Living / Research / March 23, 2012

Chances that a baby who is born with low birth weight or of shorter than the average/mean height or both growing into adult facing fragile bones is more high than for a baby who had good weight and height statistics at birth.  Researchers from the University of Southampton have teamed up with a study group in New Delhi to look at a birth cohort. A birth cohort study is one which examines persons born on the same day/period and are exposed to similar variable factors/conditions such as a drug/medical procedure or pollutant etc – that is they share some characteristics. The study is being conducted over a decade where scientists have been trying to establish a relationship between height, body mass index (BMI) and the outcomes it spells into adulthood for the cohort group. The adulthood outcomes were those of…

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Bone-Healthy Living / Research / March 15, 2012

A study from Columbia University College of Dental Medicine warns that patients who were on long term bisphosphonates medication for treating osteoporosis were at risk of developing necrosis of bones in the jaw if they carried a variation of a particular gene. It was also a caution to doctors to have their osteoporosis patients checked for this gene variation before prescribing long-term or high doses of bisphosphonates for them. (1) So what is osteonecrosis? Osteonecrosis is a disease caused by decreased blood flow to the bones and the joints. When there is limited blood flow your bone begins to break down and die. Bisphosphonates are a common class of drug that bind to the bone of the patient taking them and inhibits the production of cells called osteoclasts which are responsible for the breakdown and resorption of bone. They are…

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