AlgaeCal Research Summary

1. Changes in Total Body Bone Mineral Density Following a Common Bone Health Plan With Two Versions of a Bone Health Supplement: Comparative Effectiveness Research Study

This human study compared two AlgaeCal formulations (one of which is AlgaeCal Plus and Strontium Boost). More than 200 healthy people were involved in this study including men and women from age 18 to 85. The primary outcome measure was bone mineral density and a secondary measure was safety as reported in a panel of 43 blood tests along with quality of life questionnaire. AlgaeCal Plus and Strontium Supplement Boost group achieved an outright increase in bone density of more than 2%. Calcium studies often report an “increase in bone density”, but it is never an outright increase – it is an increase compared to the placebo group which is declining. This can be confusing, because although it is generally reported as an increase in bone density, the participants are actually losing bone. To be very clear, this AlgaeCal Plus and Strontium Boost study is a landmark result with a real increase in BMD. This study has been published in a prominent peer-reviewed journal Nutrition Journal – http://www.nutritionj.com/content/10/1/32 and in Pubmed – http://www.ncbi.nlm.nih.gov/pubmed/21492428

2. A Comparative Effectiveness Study of Bone Density Changes in Women Following Three Bone Health Plans With the Same Novel Plant-sourced Calcium

This comparative effectiveness study involving post menopausal women compared three AlgaeCal formulas to published data on traditional calcium supplements BMD scores. Post menopausal women are expected to lose approximately 1% of bone density per year with traditional calcium supplements only slowing that rate of loss slightly. This study shows each AlgaeCal group increasing bone density at one year.

This study has been published in the International Journal of Medical Sciences – http://www.medsci.org/v08p0180.htm.

3. Comparative effects of a novel plant-based calcium supplement with two common calcium salts on proliferation and mineralization in human osteoblast cells

Researchers from the Harvard Medical School and University of Connecticut, collaborate on this landmark study which was accepted for publication in an upcoming issue of the peer-reviewed journal, Molecular and Cellular Biochemistry. In direct head-to-head tests, the scientists compared the effects of AlgaeCal with the two top-sellers, calcium carbonate and calcium citrate.

Focused on the proliferation, mineralization and oxidative stress in cultured human osteoblast cells, the study results showed that AlgaeCal®, increased alkaline phosphatase activity 200 percent more effectively than calcium carbonate and 250 percent better than calcium citrate. In addition, AlgaeCal outperformed calcium carbonate and calcium citrate by 300 and 400 percent respectively on DNA synthesis – the ability of these osteoblasts to produce new bone building cells.

In other words, the AlgaeCal calcium increased the number of human bone building cells by 400 percent more than calcium carbonate.   The study findings provided evidence that AlgaeCal plant calcium is superior to the two most popular forms of calcium in all test parameters – the first time in the history of calcium research that a significant difference was shown between the many commercially available calcium ingredients’ effect on bone cells.

Pubmed listing – http://www.ncbi.nlm.nih.gov/pubmed/20213262

4. Safety and Toxicological Evaluation of AlgaeCal, A Novel Plant-based Calcium

Six different safety studies have been conducted on AlgaeCal in the United States and Europe and combined into one manuscript which has been accepted for publication in the peer-reviewed journal, Toxicology Mechanisms and Actions.  These studies include one which tested the toxicity of AlgaeCal on pregnant and nursing females.

Pubmed listing – http://www.ncbi.nlm.nih.gov/pubmed/20528255