At the May 2012 Annual Meeting of the Society-for-Investigative-Dermatology, one of the presentations, entitled “Denosumab is associated with dermatologic toxicity in the FDA-Adverse Events Reporting System (AERS) database,” discussed reports of “cutaneous ([skin] adverse events” (CAE) reported to the FDA’s AERS, from June 1, 2011 to June 30, 2012. Of the 33 reports of denosumab-associated [...]
“Treatment with vitamin K, especially MK-7, effective enough to reduce bone resorption,” say researchers reporting the results of a landmark study published April 2012 in Calcified Tissue International, a leading journal for research on the structure and function of bone.[1] This one year-long study compared the effects of vitamin K1 to those of vitamin K2 [...]
Recent findings from study conducted by researchers at University of Alberta, Canada points that heart failure patients are at increased risk of developing osteoporosis. In a study that observed 45, 500 adults over a period of ten years, it was found that heart failure is linked to thinning and weakening of the bones over a [...]
Study conducted at the Children’s Hospital Boston showed some surprising results when Kendrin R. Sonneville, Sc.D., R.D and his colleagues examined the relation between risk of stress fractures in growing girls and their intake of calcium, Vitamin D and/or dairy products. Stress fractures usually occur due to overuse of a particular bone or set of [...]
The European Medicine Agency (EMA) has issued cautionary advice to doctors on prescribing strontium ranelate, sold under brand names Osseor or Protelos by Les Labaratoires Servier, to those who are immobilised, have or run the risk of venous thromboembolism. The warning prohibits doctors from prescribing this strontium ranelate to such patients. Venous thromboembolism is a [...]
If you are not among those who are allergic to soy or have been diagnosed as having hypothyroidism, soy foods can be a great addition to your bone-building diet. Not only are soy foods excellent sources of magnesium and vitamin K1 (plus many are fortified with calcium), but they contain active compounds called isoflavones – [...]
Like the bisphosphonates, denosumab (trade names Prolia, Xgeva[i]) also prevents osteoclasts from removing old, damaged or worn out bone. It just does so via a different action than the bisphosphonates — an action that may turn out to have even more harmful side-effects. Instead of poisoning already mature osteoclasts (which is what the bisphosphonates do), [...]
Biphosphonate class drug Boniva also sold worldwide under the brand names Bonviva and Bondronat is now available for sale in the United States. The Food and Drug Administration has approved it’s use – prescription by doctors and distribution in pharmacies for sale in the prevention and treatment of osteoporosis in post-menopausal women. (1) The primary [...]
While most of the focus on osteoporosis in terms of reported cases, diagnosis, treatment, research and cost burdens have been in the US and Europe, the latest audit report (October 2011) from International Osteoporosis Foundation (IOF) shows that Middle East and Africa regions are getting left behind in the global effort towards tackling osteoporosis. The [...]
A bone growth molecule has now been developed by the scientific community which once injected into the bloodstream, ‘directs’ stem cells in the bone marrow to form more bones. The UC Davis Health System scientists have created this novel technique. The bone growth molecule which is injected is a hybrid molecule (or a double-stranded nucleic [...]
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